Comparative Study Of Two Anxiolytics On Rats: a P

Title: Comparative Study of Two Anxiolytics on Rats: a Preclinical Study Introduction: Material and Methods Animals: Adult Charles advance rats (160 ± 20 g) were obtained from primeval Animal House of Institute of health check Sciences, Banaras Hindi University, Varanasi. The animals were housed in groups of six in polypropylene cages at an ambient temperature of 25 ± 1ºC and 45-55 % relative humidity, with a 12:12 h light/dark cycle. Animals were provided with commercialized diet pellets and water ad libitum, except stated otherwise. both the animals were acclimatized to research laboratory conditions for at least one hebdomad before apply them for the experiments. Principles of laboratory animal care (NIH result turning 85-23, revise 1985) guidelines were followed. Prior approval for animal experimental work from the Central Animal Ethical Committee of the University. line of battle I rule (0.3 % CMC vehicle treated) base II do drugs A 1 concourse III dose A 2 Group IV Drug A 3 Group V Drug B 1 Group VI Drug B 2 Group septette Drug B S. No.| Name of Drug (Generic Name)| MOA| rank| 1.| lorazepam| | Benzodiazepine| 2.| Diazepam| | Benzodiazepine| 3.| Alprazolam| | Benzodiazepine| Animal Models: Anxiolytic act 1. Elevated plus- inner ear render (EPM): The method of Pellow et al. (1986) was followed. The maze had two inverse mail, 50 × 10 cm, crossed with two enclosed arms of the same proportionality but having 40 cm heights walls. The arms were committed with a central square, 10 × 10 cm, giving the utensil shape of a plus sign. The maze was kept in a dimly lit way and elevated 50 cm above the floor. Naive rats were primed(p) individually in centre of the maze, facing an enclosed arm. Thereafter, number of entries and time spend on the open and enclosed arms were recorded during the attached 5 min. An arm entry was define when all quaternion paws of the rats were in the arm (Kumar et al., 2000) neutral screen observer make observations. ! 2. Open-field test (OFT):...If you want to get a full essay, ready it on our website: OrderEssay.net

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